Ocular Melanoma Foundation | OMFOcular melanoma (“OM” for short) is a cancer of the eye diagnosed in approximately 2,0. United States. In both the U. S. and Europe, this equates to about 5 - 7.
Similar to melanoma of the skin, OM is a little understood and silent killer. In the majority of cases, ocular melanoma develops slowly from the pigmented cells of the choroid (choroidal melanoma) but it also can develop from the pigmented cells of the iris and ciliary body. You may hear it called uveal melanoma because the uvea is a part of the eye containing two areas in which OM can commonly occur.
OM is an aggressive form of cancer that can involve any of three areas of the eye: the iris (the pigmented area surrounding your pupil), the ciliary body (a thin tissue layer in your eye responsible for aqueous humor production), and/or the choroid or posterior uvea (the vascular layer of the eye between the retina and the white outer layer known as the sclera; this pigmented tissue full of blood vessels nourishes the retina). These three areas are collectively known as the uvea or uveal tract, and OM can occur in any combination of the three. Iris melanomas have the best prognosis, whereas melanomas of the ciliary body have the worst.
Melanoma Facts & Pictures. Melanoma begins in the melanocytes, the cells that make melanin which is the pigment that determines your natural skin color. General Background Uveal melanoma is a malignant cancer of the eye in adults. It is rare – there are only an estimated 1200-1800 cases per year in the United.
Most uveal tract melanomas originate in the choroid; the ciliary body is less commonly a site of origin, and the iris is the least common. Melanoma can also occur in the thin lining over the white part of the eye (the conjunctiva) or on the eyelid, but this is very rare. OM tumors arise from the pigment cells (melanocytes) that give color to the eye. Formation of these tumors is quite rare and, as for many other forms of cancer, the exact cause is unknown. It is known that exposure to ultraviolet (UV) rays (either from the sun or sunbeds) increases the risk of developing melanoma of the skin. People whose skin burns easily are most at risk – people with fair skin, fair or red hair and blue eyes. However, there has no conclusive evidence linking UV exposure and OM.
Ocular melanoma may be more common in people who have atypical mole syndrome, which is also called dysplastic naevus syndrome. People with this condition have a greater risk of developing a melanoma of the skin, and often have over 1. Approximately 2,5. There is no known cause, though incidence is highest among people with lighter skin and blue eyes. Approximately 5. 0% of patients with OM will develop metastases by 1. Metastatic disease is universally fatal. This 5. 0% mortality rate is unchanged despite treatment advances in treating the primary eye tumor.
More research is needed urgently to improve patient outcomes.
- Lentigo maligna melanoma is a melanoma that has evolved from a lentigo maligna. :695 They are usually found on chronically sun damaged skin such as the face and.
- Clinical Presentations Rapidly spreading darkly pigmented patch with irregular border Invasion associated with papules, plaques and later.
- More comprehensive melanoma check/skin cancer check (doctor's check) than is possible with mole mapping alone. Types of skin cancer described.